In this work a thermo-mechanical fatigue application, related to a crack propagation in an aircraft turbine vane undergoing a complex load spectrum, is simulated. A computationally efficient FEM-DBEM submodelling approach, whose implementation leverages on the principle of linear superposition, is adopted. When tackling a crack propagation problem with a FEM-DBEM combined approach, the global analysis is generally worked out by FEM whereas the fracture problem is solved in a DBEM environment. In particular, a DBEM submodel is extracted from the global uncracked FEM model and, generally, is loaded on the boundaries with temperatures and either displacements or tractions; then the crack propagation is simulated by repeated thermal-stress D...