Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng

Tan, Siow Ping
Ali, Abdul Manaf
Nafiah, Mohd Azlan
Awang, Khalijah
Ahmad, Kartini

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Publication date

January 2015

DOI

10.1016/j.tet.2015.04.037

Publisher

Elsevier BV

Abstract

Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2-4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigii (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50<20 μg/mL) via MTT assay

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Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng

Abstract

Extracted data

Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng

Abstract

Extracted data

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