Antimalarial interventions have yielded a significant decline in malaria prevalence in The Gambia, where artemether-lumefantrine (AL) has been used as a first-line antimalarial for a decade. Clinical Plasmodium falciparum isolates collected from 2012 to 2015 were analyzed ex vivo for antimalarial susceptibility and genotyped for drug resistance markers (pfcrt K76T, pfmdr1 codons 86, 184, and 1246, and pfk13) and microsatellite variation. Additionally, allele frequencies of single nucleotide polymorphisms (SNPs) from other drug resistance-associated genes were compared from genomic sequence data sets from 2008 (n = 79) and 2014 (n = 168). No artemisinin resistance-associated pfk13 mutation was found, and only 4% of the isolates tested in 201...
BACKGROUND: Artemisinin-based combination therapy (ACT) reduces the potential for malaria transmissi...
The artemisinin-based combination therapies artemether-lumefantrine (AL) and amodiaquine (AQ) plus a...
Resistance to anti-malarials is a major public health problem worldwide. After deployment of artemis...
Antimalarial interventions have yielded a significant decline in malaria prevalence in The Gambia, w...
Background. Artemether-lumefantrine (AL) is a major and highly effective artemisinin-based combinati...
Monitoring of Plasmodium falciparum sensitivity to antimalarial drugs in Africa is vital for malaria...
Background. Multidrug-resistant Plasmodium falciparum is a major threat to global malaria control. P...
Background: Development and spread of Plasmodium falciparum resistance to artemisinin-based combinat...
Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (A...
Monitoring of Plasmodium falciparum sensitivity to antimalarial drugs in Africa is vital for malaria...
Background: Artemether-lumefantrine (AL) is a major and highly effective artemisinin-based combinati...
BACKGROUND: Resistance to anti-malarials is a major public health problem worldwide. After deploymen...
Background: The emergence of drug resistance is a major problem in malaria control. Combination of m...
Background: Zanzibar has recently undergone a rapid decline in Plasmodium falciparum transmission fo...
BACKGROUND: Drug resistance is a major problem to control Plasmodium falciparum infection in endemic...
BACKGROUND: Artemisinin-based combination therapy (ACT) reduces the potential for malaria transmissi...
The artemisinin-based combination therapies artemether-lumefantrine (AL) and amodiaquine (AQ) plus a...
Resistance to anti-malarials is a major public health problem worldwide. After deployment of artemis...
Antimalarial interventions have yielded a significant decline in malaria prevalence in The Gambia, w...
Background. Artemether-lumefantrine (AL) is a major and highly effective artemisinin-based combinati...
Monitoring of Plasmodium falciparum sensitivity to antimalarial drugs in Africa is vital for malaria...
Background. Multidrug-resistant Plasmodium falciparum is a major threat to global malaria control. P...
Background: Development and spread of Plasmodium falciparum resistance to artemisinin-based combinat...
Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (A...
Monitoring of Plasmodium falciparum sensitivity to antimalarial drugs in Africa is vital for malaria...
Background: Artemether-lumefantrine (AL) is a major and highly effective artemisinin-based combinati...
BACKGROUND: Resistance to anti-malarials is a major public health problem worldwide. After deploymen...
Background: The emergence of drug resistance is a major problem in malaria control. Combination of m...
Background: Zanzibar has recently undergone a rapid decline in Plasmodium falciparum transmission fo...
BACKGROUND: Drug resistance is a major problem to control Plasmodium falciparum infection in endemic...
BACKGROUND: Artemisinin-based combination therapy (ACT) reduces the potential for malaria transmissi...
The artemisinin-based combination therapies artemether-lumefantrine (AL) and amodiaquine (AQ) plus a...
Resistance to anti-malarials is a major public health problem worldwide. After deployment of artemis...