Polyclonal CD8⁺ T cells from the lungs of Mtb-infected mice recognize infected macrophages.

<p>IFNγ production by polyclonal CD4⁺ (a) or CD8⁺ (b) T cells after co-culture with either MHC-matched (H-2^b) or MHC-mismatched (H-2^k), Mtb-infected macrophages. IFNγ production by TB10.4₄₋₁₁-tetramer-depleted (c) or tetramer-enriched (d) polyclonal CD8⁺ T cells after co-culture with either MHC-matched (H-2^b) or MHC-mismatched (H-2^k), Mtb-infected macrophages. Data is representative of at least 2 experiments. Statistical testing by a two-tailed, unpaired Student’s T test. *, p<0.05; **, p<0.01; and ***, p<0.005.