Polymorphic sites preferentially avoid co-evolving sites and sites involved in protein stability.

<p><b>Top.</b> Plots of polymorphism scores versus: (A) DCA scores, (B) stability scores measured using FoldX (AlaScan function), (C) number of structural contacts. <b>Bottom.</b> Enrichment analysis of non-polymorphic sites with respect to (A) DCA scores, (B) stability scores and (C) number of structural contacts (x-axis shows the ranking of sites based on these values, sites with a polymorphism score lower than 0.01 are shown in yellow).