Normalizing intrinsic dendritic excitability limits SCA1 Purkinje neuron dendritic degeneration.

<p><b>(A)</b> Representative images at the cerebellar primary fissure in wild-type mice, ATXN1[82Q] mice exposed to sham surgery and vehicle, ATXN1[82Q] mice exposed to sham surgery and baclofen, and ATXN1[82Q] mice exposed to BK-AAV and baclofen. Scale bar, 50 μm. <b>(B)</b> Molecular layer thinning is reduced at fourteen weeks in ATXN1[82Q] mice injected with BK-AAV and treated with baclofen. Data are mean ± SEM. * = statistically-significant difference from wild-type and ATXN1[82Q] BK-AAV + Baclofen groups; # = statistically-significant difference from all other groups. Statistical significance derived by one-way ANOVA with Holm-Sidak multiple comparison test.