MOESM1 of Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

Additional file 1: Table S1. IC50 = micromolar (μM) concentration at which harmine inhibits 50% of viable cells. +/− standard deviation (n = 3). N/D = not done (50% inhibition was not reached). Fig. S1. Micrographs depicting the effects of 100 μM harmine on four different human neuroblastoma cell lines. Pictures were taken at 24, 48, and 72 h after exposure to the harmine. The 72 h micrographs are included as a part of Fig. 2. Fig. S2. PARP cleavage was detected after 24 h of harmine treatment at increasing concentrations (0–200 μM) using Western blot. Higher concentrations of harmine are required to detect the cleavage of PARP in the SKNAS and SKNFI cell lines after a 24 h treatment. Data are representative of three independent experiments (n = 3)