Recombination patterns reported for <i>S</i>. <i>pneumoniae</i> in nature and <i>in vitro</i>.

<p>Frequencies of recombination events as a function of segment size, plotted for six retrospective global analyses of exchange events in nature and one global analysis of products of genetic transformation <i>in vitro</i>. Recombinant segments were aggregated in 2-kbp increments. Panels display both the number of events in each size class (<b>blue</b>) and total mass of DNA (kbp) incorporated during those events (<b>orange</b>). Data extracted from cited publications. <b>A.</b> 173 strains of the PMEN4 lineage: 451 events total. [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007410#pgen.1007410.ref012" target="_blank">12</a>]. <b>B.</b> 189 strains of the PMEN2 lineage: 616 events total [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007410#pgen.1007410.ref055" target="_blank">55</a>]. <b>C.</b> Two vaccine escape strains: 27 events total [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007410#pgen.1007410.ref010" target="_blank">10</a>]. <b>D.</b> Two ST13 strains from one patient: 23 events total [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007410#pgen.1007410.ref011" target="_blank">11</a>]. <b>E.</b> 241 strains of the PMEN1 lineage: ~800 events total [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007410#pgen.1007410.ref056" target="_blank">56</a>]. <b>F.</b> 426 strains receiving DNA from PMEN1 lineage: ~24 events total [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007410#pgen.1007410.ref004" target="_blank">4</a>]. <b>G.</b> 84 strains of PMEN1 strain 23-F-R transformed by Kan^R DNA from strain TIGR4: 107 RSS events [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007410#pgen.1007410.ref009" target="_blank">9</a>].