Hyperactivity of P53 signaling in the NCC-<i>mTOR</i> KO mice.

<p>(A) Western blots for Mdm2, P53, P21 and Bax of E10.5 and E11.5 facial primordia. (B) Quantification of western blots of Mdm2, P53, P21 and Bax. (C, D) Immunofluorescence for P53 in the mandibular prominence of E10.5 mice. (E, F) Immunofluorescence for β-galactosidase in the mandibular arch of E14.5 mice. Note, a number of positive cells are present in mutant mandibular arch. (G) Quantification of β-galactosidase positive cells. **P<0.01. β-gal: β-galactosidase; ctr: control; md: mandible; oe: oral epithelium; tb: tooth bud; ton: tongue. Scale bar: 100μm.