Add to ORKGp53 is an important tumor suppressor gene which is mutated in ~50% of all human cancers. Some of the p53 mutants appear to have acquired novel functions beyond merely losing wild-type functions. To investigate these gain-of-function effects in vivo, we interbred MMTV-v-Ha-ras transgenic mice to either p53-/- knock-out mice or p53R172H/+ knock-in mice to generate mice of three different genotypes: MMTV-ras, MMTV-ras/p53-/-, and MMTV-ras/p53R172H/R172H. Male mice of each of these genotypes were characterized with regard to age of salivary tumor onset and the tumors were characterized with regard to mean growth rates, proliferation fraction, apoptotic levels, and tumor histopathology, as well as responses to doxorubicin treatment. Microarray a...
Although p53 mutations in tumors typically result in loss of transactivation of p53 target genes som...
Missense mutations in the p53 tumor-suppressor gene are the most common alterations of p53 in somati...
Missense mutant forms of p53 are expressed at high lev-els in some human cancers and may contribute ...
p53 is an important tumor suppressor gene which is mutated in ~50% of all human cancers. Some of the...
<div><p><i>p53</i> is an important tumor suppressor gene which is mutated in ~50% of all human cance...
p53 is an important tumor suppressor gene which is mutated in ~50 % of all human cancers. Some of th...
p53 is an important tumor suppressor gene which is mutated in ~50% of all human cancers. Some of the...
BACKGROUND: The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, in...
Mutations in the p53 tumor suppressor gene are found in over 50% of human tumors and in the germline...
Mutations in the p53 tumor suppressor gene are found in over 50% of human tumors and in the germline...
Pleomorphic rhabdomyosarcoma is the most common variant of this tumour in adults and has a very poor...
The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mu...
p53 is frequently altered in human tumors through missense mutations that result in accumulation of ...
To study the role of mutant p53 in the induction and cure of tumors, we generated transgenic mice ca...
Studies in mice have yielded invaluable insight into our understanding of the p53 pathway. Mouse mod...
Although p53 mutations in tumors typically result in loss of transactivation of p53 target genes som...
Missense mutations in the p53 tumor-suppressor gene are the most common alterations of p53 in somati...
Missense mutant forms of p53 are expressed at high lev-els in some human cancers and may contribute ...
p53 is an important tumor suppressor gene which is mutated in ~50% of all human cancers. Some of the...
<div><p><i>p53</i> is an important tumor suppressor gene which is mutated in ~50% of all human cance...
p53 is an important tumor suppressor gene which is mutated in ~50 % of all human cancers. Some of th...
p53 is an important tumor suppressor gene which is mutated in ~50% of all human cancers. Some of the...
BACKGROUND: The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, in...
Mutations in the p53 tumor suppressor gene are found in over 50% of human tumors and in the germline...
Mutations in the p53 tumor suppressor gene are found in over 50% of human tumors and in the germline...
Pleomorphic rhabdomyosarcoma is the most common variant of this tumour in adults and has a very poor...
The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mu...
p53 is frequently altered in human tumors through missense mutations that result in accumulation of ...
To study the role of mutant p53 in the induction and cure of tumors, we generated transgenic mice ca...
Studies in mice have yielded invaluable insight into our understanding of the p53 pathway. Mouse mod...
Although p53 mutations in tumors typically result in loss of transactivation of p53 target genes som...
Missense mutations in the p53 tumor-suppressor gene are the most common alterations of p53 in somati...
Missense mutant forms of p53 are expressed at high lev-els in some human cancers and may contribute ...