Effect of lobeglitazone (Lobe) on hepatic lipogenesis in high-fat diet (HFD)-fed mice.

<p>Western blots and quantification of hepatic (A) peroxisome proliferator-activated receptor (PPAR) α, (B) PPARγ, (C) fatty acid synthase (FAS), (D) stearoyl-CoA desaturase (SCD) 1, (E) diglyceride acyltransferase (DGAT) 1, and (F) carbohydrate response element binding protein (ChREBP)-1 expression in normal diet (ND), non-treated HFD, Lobe-treated HFD (1 or 5 mg/kg/d), and Lobe-only mice. Densitometry values for each protein are normalized to β-actin or p84. Data are presented as mean ± SEM. *<i>P</i> <0.05 vs. ND-fed mice; †<i>P</i> <0.05 vs. HFD-fed mice.