<p>Strains Silvio X10/7, Y and PAH1790 assessed after 5 days treatment with nifurtimox <b>(A)</b> benznidazole <b>(B)</b> and posaconazole <b>(C)</b>. (Representative dose-response curves of at least 3 biological replicates normalised to 0% effect DMSO and 100% effect 50 μM nifurtimox controls. Average±SD). The x axis is the Log of the compound concentration in Molar.</p
<p>(A): Parasitemia curve, and (B) Ponderal Curve of infected mice treated or not for twenty daily d...
<p>The activity of 5 (E–F), 12.5 and 25 (A–D) mg/Kg/day of DB1965 (ip) and 100 mg/kg/day DB1965 via ...
<p>The activity of the compounds against bloodstream trypomastigotes (BT) and intracellular parasite...
<p>Silvio X10/7 <b>(A-C)</b> and Tulahuen βgal <b>(D-F)</b> trypomastigotes after 24, 48 and 72 h tr...
<p>pEC<sub>50</sub> = –Log (EC<sub>50</sub> [M]), average of at least three biological replicates ± ...
1<p>Swiss female (n = 10) weight 20 to 24 g were inoculated with 5×10<sup>3</sup> trypomastigotes (V...
1<p>Swiss male mice weight 20 to 24 g inoculated with 10<sup>4</sup> blood trypomastigotes (Y strain...
1<p>Swiss male mice weight 20 to 24 g inoculated with 10<sup>4</sup> blood trypomastigotes (Y strain...
Benznidazole and nifurtimox-treatments regimens currently used in human are supported by very limite...
<p>Maximum number of trypomastigote forms detected in the peripheral blood of mice infected with <i>...
1<p>Swiss female (n = 10) weight 20 to 24 g were inoculated with 5×10<sup>3</sup> trypomastigotes (Y...
<p>pEC<sub>50</sub> = –Log (EC<sub>50</sub> [M]), average of at least three biological replicates ± ...
Indicated concentration of benznidazole (A) or nifurtimox (B) was added to the culture of axenic ama...
Benznidazole and nifurtimox, the currently available drugs for the specific treatment of Chagas dise...
<p>A) Structures of GNF7686, benznidazole and prototypic cytochrome <i>b</i> inhibitors used in this...
<p>(A): Parasitemia curve, and (B) Ponderal Curve of infected mice treated or not for twenty daily d...
<p>The activity of 5 (E–F), 12.5 and 25 (A–D) mg/Kg/day of DB1965 (ip) and 100 mg/kg/day DB1965 via ...
<p>The activity of the compounds against bloodstream trypomastigotes (BT) and intracellular parasite...
<p>Silvio X10/7 <b>(A-C)</b> and Tulahuen βgal <b>(D-F)</b> trypomastigotes after 24, 48 and 72 h tr...
<p>pEC<sub>50</sub> = –Log (EC<sub>50</sub> [M]), average of at least three biological replicates ± ...
1<p>Swiss female (n = 10) weight 20 to 24 g were inoculated with 5×10<sup>3</sup> trypomastigotes (V...
1<p>Swiss male mice weight 20 to 24 g inoculated with 10<sup>4</sup> blood trypomastigotes (Y strain...
1<p>Swiss male mice weight 20 to 24 g inoculated with 10<sup>4</sup> blood trypomastigotes (Y strain...
Benznidazole and nifurtimox-treatments regimens currently used in human are supported by very limite...
<p>Maximum number of trypomastigote forms detected in the peripheral blood of mice infected with <i>...
1<p>Swiss female (n = 10) weight 20 to 24 g were inoculated with 5×10<sup>3</sup> trypomastigotes (Y...
<p>pEC<sub>50</sub> = –Log (EC<sub>50</sub> [M]), average of at least three biological replicates ± ...
Indicated concentration of benznidazole (A) or nifurtimox (B) was added to the culture of axenic ama...
Benznidazole and nifurtimox, the currently available drugs for the specific treatment of Chagas dise...
<p>A) Structures of GNF7686, benznidazole and prototypic cytochrome <i>b</i> inhibitors used in this...
<p>(A): Parasitemia curve, and (B) Ponderal Curve of infected mice treated or not for twenty daily d...
<p>The activity of 5 (E–F), 12.5 and 25 (A–D) mg/Kg/day of DB1965 (ip) and 100 mg/kg/day DB1965 via ...
<p>The activity of the compounds against bloodstream trypomastigotes (BT) and intracellular parasite...