Effect of changes in BK_Ca and SK_Ca maximum conductance on the train of APs and [Ca]_i.

<p>The maximum conductance of BK_Ca and SK_Ca channels were changed between of 9*10⁻⁴ (control value) to 4.5*10⁻³ S/cm² for both SK_Ca and BK_Ca) individually and the model was stimulated with 1000 ms rectangular current clamp of 0.12 nA amplitude. The number of spikes (A) and peak intracellular Ca²⁺ concentration, [Ca]_i (B) were recorded at every increment of BK_Ca (filled circles) and SK_Ca (filled triangles) maximum conductance.