<p>Membrane potential, V<sub>m</sub> (upper panel), intracellular calcium concentration, [Ca]<sub>i</sub> (middle panel) and instantaneous SK<sub>Ca</sub> conductance, <i>g</i> (lower panel) recorded against time for three maximum conductances () of the SK<sub>Ca</sub> channel: 9*10<sup>−4</sup> S/cm<sup>2</sup> (control) (A, D, G), 2.7*10<sup>−3</sup> S/cm<sup>2</sup> (B, E, H) and 4.5*10<sup>−3</sup> S/cm<sup>2</sup> (C, F, I). The neuron model used had SK<sub>Ca</sub> channels endowed with inward rectification (SK<sub>Ca</sub> with IR). Stimulus: 1000 ms, 0.12 nA rectangular current clamp.</p
<p>representative trace showing attenuation of CCK (10 nM) induced increase in cytosolic calcium fol...
Key points center dot Active calcium signal propagation occurs when an initial calcium trigger elici...
Key points center dot Active calcium signal propagation occurs when an initial calcium trigger elici...
<p>Membrane potential, V<sub>m</sub> (upper panel), intracellular calcium concentration, [Ca]<sub>i<...
<p>The calcium-dependent parameter <i>o</i> (A and B), inward rectification (IR) parameter, <i>m</i>...
<p>(Upper panel, A-C) AP generated in bladder small DRG neuron soma model with SK<sub>Ca</sub> posse...
<p>Comparison of RMP (A), AP Duration (B), AP overshoot (C), AHP Amplitude (D), Time to AHP Peak (E)...
<p>(A) The voltage dependent inward rectification (IR) parameter, <i>m</i> as a function of [Ca]<sub...
<p>The maximum conductance of BK<sub>Ca</sub> and SK<sub>Ca</sub> channels were changed between of ...
<p>(A) The AP firing in the bladder capsaicin-sensitive (or small-diameter) DRG neuron soma in bladd...
Bladder small DRG neurons, which are putative nociceptors pivotal to urinary bladder function, expre...
*<p>The reversal potential of the calcium conductances, E<sub>ca</sub>, was calculated at each simul...
Bladder small DRG neurons, which are putative nociceptors pivotal to urinary bladder function, expre...
<div><p>Bladder small DRG neurons, which are putative nociceptors pivotal to urinary bladder functio...
<p>Top panel: effects of the mean maximal conductance <math><mrow><mi>g</mi></mrow><mo>-</mo></math>...
<p>representative trace showing attenuation of CCK (10 nM) induced increase in cytosolic calcium fol...
Key points center dot Active calcium signal propagation occurs when an initial calcium trigger elici...
Key points center dot Active calcium signal propagation occurs when an initial calcium trigger elici...
<p>Membrane potential, V<sub>m</sub> (upper panel), intracellular calcium concentration, [Ca]<sub>i<...
<p>The calcium-dependent parameter <i>o</i> (A and B), inward rectification (IR) parameter, <i>m</i>...
<p>(Upper panel, A-C) AP generated in bladder small DRG neuron soma model with SK<sub>Ca</sub> posse...
<p>Comparison of RMP (A), AP Duration (B), AP overshoot (C), AHP Amplitude (D), Time to AHP Peak (E)...
<p>(A) The voltage dependent inward rectification (IR) parameter, <i>m</i> as a function of [Ca]<sub...
<p>The maximum conductance of BK<sub>Ca</sub> and SK<sub>Ca</sub> channels were changed between of ...
<p>(A) The AP firing in the bladder capsaicin-sensitive (or small-diameter) DRG neuron soma in bladd...
Bladder small DRG neurons, which are putative nociceptors pivotal to urinary bladder function, expre...
*<p>The reversal potential of the calcium conductances, E<sub>ca</sub>, was calculated at each simul...
Bladder small DRG neurons, which are putative nociceptors pivotal to urinary bladder function, expre...
<div><p>Bladder small DRG neurons, which are putative nociceptors pivotal to urinary bladder functio...
<p>Top panel: effects of the mean maximal conductance <math><mrow><mi>g</mi></mrow><mo>-</mo></math>...
<p>representative trace showing attenuation of CCK (10 nM) induced increase in cytosolic calcium fol...
Key points center dot Active calcium signal propagation occurs when an initial calcium trigger elici...
Key points center dot Active calcium signal propagation occurs when an initial calcium trigger elici...