In the Sparse Linear Regression (SLR) problem, given a d x n matrix M and a d-dimensional query q, the goal is to compute a k-sparse n-dimensional vector tau such that the error ||M tau - q|| is minimized. This problem is equivalent to the following geometric problem: given a set P of n points and a query point q in d dimensions, find the closest k-dimensional subspace to q, that is spanned by a subset of k points in P. In this paper, we present data-structures/algorithms and conditional lower bounds for several variants of this problem (such as finding the closest induced k dimensional flat/simplex instead of a subspace). In particular, we present approximation algorithms for the online variants of the above problems with query time O~(n^{...