The use of sparsity has emerged in the last fifteen years as an important tool for solving many problems in the areas of signal processing and statisticalinference. In this dissertation we pursue three significant applications of sparsity; sparse linear regression, low rank matrix completion and sparseinverse covariance selection. In the first and third topic, sparsity refers to having a small number of nonzero vector and matrix entries respectively,while in the second topic it is associated with low matrix rank.A penalized approach is considered involving optimization of an objective function with two terms. One of the terms measures the goodness of fit i.e.the error between the observed data and the estimated solution, while the other is ...