Internal Model Control (IMC) yields very good performance for set point tracking, but gives sluggish response for disturbance rejection problem. A two-degree-of-freedom IMC (2DOF-IMC) has been developed to overcome the weakness. However, the setting of parameter becomes a complicated matter if there is an uncertainty model. The present study implements a new tuning method for the controller. The proposed tuning method consists of three steps: Firstly, determine the worst case of the model uncertainty. Secondly, specify the parameter of set point controller using maximum peak (Mp) criteria. And finally, obtain the parameter of the disturbance rejection controller using gain margin (GM) criteria. The method is denoted as MpGM tuning method. ...