Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3+ T cells
- González, Florencia Belén
- Villar, Silvina Raquel
- Fernández Bussy, Rodrigo
- Martin, Gaëlle H.
- Pérol, Louis
- Manarin, Romina
- Spinelli, Silvana Virginia
- Pilon, Caroline
- Cohen, José Laurent
- Bottasso, Oscar Adelmo
- Piaggio, Eliane
- Perez, Ana Rosa
DOIAbstract
We previously showed that Trypanosoma cruzi infection in C57BL/6 mice results in a lethal infection linked to unbalanced pro- and anti-inflammatory mediators production. Here, we examined the dynamics of CD4+ Foxp3+ regulatory T (Treg) cells within this inflammatory and highly Th1-polarized environment. Treg cells showed a reduced proliferation rate and their frequency is progressively reduced along infection compared to effector T (Teff) cells. Also, a higher fraction of Treg cells showed a naïve phenotype, meanwhile Teff cells were mostly of the effector memory type. T. cruzi infection was associated with the production of pro- and anti-inflammatory cytokines, notably IL-27p28, and with the induction of T-bet and IFN-c expression in Treg ...
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