ASSESSMENT OF RELATION BETWEEN MICROALBUMINURIA AND ISCHEMIC ELECTROCARDIOGRAM IN IRANIAN GENERAL POPULATION

<p class="abstract"><strong>Abstract</strong></p> <p class="abstract"><strong>&nbsp;&nbsp; BACKGROUND:</strong><strong> </strong>Enhancement of albumin exertion in urine increases the risk of renal and ischemic heart diseases (IHD). We assessed the association of urine albumin and sub-clinical IHD in a random sample of Iranian general population.</p> <p class="abstract"><strong>&nbsp;&nbsp; METHODS</strong>: The random sample in general population in Isfahan County was recruited to the cross-sectional study. From the all sample blood pressure and lipid profile were assessed and morning urine spot was measured for albumin and Creatinine. Microalbuminuria was defined either Albumin-Creatinine Ratio (ACR) was 30-300mg. Also, the standard 12 lead electrocardiogram (ECG) was carried out for all participants. The ECG pattern was divided to two categories; normal or ECG with ischemia. The logistic regression model was determined the odds of albuminuria for ischemic changes in ECG.</p> <p class="abstract"><strong>&nbsp;&nbsp; RESULTS: </strong>999 subjects, age 35-70 years, participated to study. From all, 40.8% were male. Microalbuminuria was detected in 8% and sub-clinical ECG ischemic changes were found in 23.4%. The most frequent ischemic change was T wave inversion. The mean urine albumin levels in subjects with normal ECG was 9.6&plusmn;14.6 mg/ml and in ischemic group was 8.5&plusmn;12.2 mg/ml and they did not have statistically different. The odds ratios of neither Albumin-Creatinine ratio nor microalbuminuria were in significant range for risk to ischemic changes in ECG of apparently healthy participants. They was consecutively OR=0.9 (0.51-1.6), OR=0.99 (0.98-1.004).<strong>&nbsp;</strong></p> <p class="abstract"><strong>&nbsp;&nbsp; CONCLUSION</strong>: Our finding didn&rsquo;t declare any association between ACR and IHD. Because of showing this association in the other study; it needs more exploration regarding to association between microalbuminuria and cardiovascular diseases incidence.</p> <p class="abstract">&nbsp;</p><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td width="35" height="12"><br /></td></tr> <tr><td><br /></td> <td>&nbsp;</td></tr></tbody></table><p class="abstract">&nbsp;</p> <br /> <p class="abstract"><strong>Keywords:</strong> Ischemic heart diseases, electrocardiogram, Albumin-Creatinine Ratio, Urine Albumin