Additional file 2: of Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells

Figure S2. Medulloblastoma xenograft histology. NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice were injected with DAOY-GL tumor cells, as described in Methods, and treated with human CD19 CAR T cells intratumorally (A) or intravenously (B). Mice were euthanized at day 22 post-treatment and brain tissue was collected for histology. Brains were sectioned and stained using H&E. Images were taken using a digital slide scanner at 10X magnification, with representative results shown above. DAOY-GL cells mainly formed tumors along the periphery of the cerebellum (indicated by black arrows), but can also be seen infiltrating into the parenchyma adjacent to normal cerebellar cells (indicated by red arrow). (PPTX 5146 kb