<p>The plots are generated using parameters in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0196508#pone.0196508.t001" target="_blank">Table 1</a></b>. Left: equilibrium (i.e., <i>t</i> → ∞) values of the Hodgkin-Huxley parameters. As labeled, gNa and gK are proportional to m<sup>3</sup> and n<sup>4</sup> respectively, and, h is proportional to the availability (or inactivation status) of the Na conductance. Right: time constants for these processes (see text for more explanation). For tau<sub>h</sub> (V) curves, the voltage regions dominated by the recovery and the inactivation processes are indicated.</p
<p>(A) Normalised <i>I</i><sub>Kv6.1</sub> current trace in simulated voltage-clamp experiments. Cur...
<p>A: Activation at 22 °C: family of current tracings recorded in a single cell in response to hyper...
<p>(A) and (B) Representative current traces of WT and L233W and Q244W, respectively, recorded as in...
<p>The activation and inactivation gating variables for each of the 7 active membrane conductances u...
<p>Aa shows representative raw traces were elicited by a series of voltage champs from a holding pot...
<p><i>A.</i> Mean values of <i>I-V</i> relationships of I<sub>Na.TTX</sub> and I<sub>Na.TTXR</sub>. ...
<p>The hysteresis regions are shaded gray. A) Increase in <i>g</i><sub>K</sub> expands the oscillato...
A variety of experimental observations in Myxicola and other preparations indicate that the sodium c...
<p>(A) Equilibrium values of the gating variables for the Na (left) and K (right) channels. (B) Volt...
<p>For the compound outward current in male and female wild-type (KChIP2<sup>+/+</sup>) myocytes the...
<p>A. The maximum of Na<sup>+</sup> inactivation time constant τ<sub>h</sub> decreases as temperatur...
<p>A: Decay from peak of activation during a voltage-clamp of -10 mV in Nav 1.1 modelled channel. Th...
<p><i>a</i>, Activation curve of the Ba<sup>2+</sup> current. The mean currents were normalized to t...
(A) Representative current traces from an oocyte expressing Kv1.2-R294H-A351H-D352G-E353S channels r...
A) Time to peak at two voltages -45 mV and 0 mV starting from a holding potential of -86.2 mV as in ...
<p>(A) Normalised <i>I</i><sub>Kv6.1</sub> current trace in simulated voltage-clamp experiments. Cur...
<p>A: Activation at 22 °C: family of current tracings recorded in a single cell in response to hyper...
<p>(A) and (B) Representative current traces of WT and L233W and Q244W, respectively, recorded as in...
<p>The activation and inactivation gating variables for each of the 7 active membrane conductances u...
<p>Aa shows representative raw traces were elicited by a series of voltage champs from a holding pot...
<p><i>A.</i> Mean values of <i>I-V</i> relationships of I<sub>Na.TTX</sub> and I<sub>Na.TTXR</sub>. ...
<p>The hysteresis regions are shaded gray. A) Increase in <i>g</i><sub>K</sub> expands the oscillato...
A variety of experimental observations in Myxicola and other preparations indicate that the sodium c...
<p>(A) Equilibrium values of the gating variables for the Na (left) and K (right) channels. (B) Volt...
<p>For the compound outward current in male and female wild-type (KChIP2<sup>+/+</sup>) myocytes the...
<p>A. The maximum of Na<sup>+</sup> inactivation time constant τ<sub>h</sub> decreases as temperatur...
<p>A: Decay from peak of activation during a voltage-clamp of -10 mV in Nav 1.1 modelled channel. Th...
<p><i>a</i>, Activation curve of the Ba<sup>2+</sup> current. The mean currents were normalized to t...
(A) Representative current traces from an oocyte expressing Kv1.2-R294H-A351H-D352G-E353S channels r...
A) Time to peak at two voltages -45 mV and 0 mV starting from a holding potential of -86.2 mV as in ...
<p>(A) Normalised <i>I</i><sub>Kv6.1</sub> current trace in simulated voltage-clamp experiments. Cur...
<p>A: Activation at 22 °C: family of current tracings recorded in a single cell in response to hyper...
<p>(A) and (B) Representative current traces of WT and L233W and Q244W, respectively, recorded as in...