<p>The activation and inactivation gating variables for each of the 7 active membrane conductances used are shown. Solid lines represent activation curves and the dotted lines represent inactivation curves. All conductances except the calcium sensitive potassium conductance have been used in previous heartbeat system models <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079267#pone.0079267-Garcia1" target="_blank">[8]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079267#pone.0079267-Hill1" target="_blank">[57]</a>.</p
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p>(A) Average peak currents normalized to cell capacitance. Smooth curves represent fits to the ave...
<p>Full lines represent activation curves. Dashed lines represent inactivation curves. Time-constant...
<p><i>ρ</i> represents the postulated number of gates, <i>m</i><sub>∞</sub> is the steady-state acti...
<p>(<b>A–E</b>), typical superimposed current traces. The inset illustrates voltage protocol. The bl...
<p>A: Decay from peak of activation during a voltage-clamp of -10 mV in Nav 1.1 modelled channel. Th...
<p>In the first three rows, we illustrated the different electrophysiological features of the three ...
<p>(A) Steady-state activation as function of voltage. (B) Time constants of inactivation as functio...
<p>The graphs show the membrane potential of the PG cell model in response to a depolarizing current...
This study aimed to elucidate the mechanisms underlying the divergent action potential (AP) morpholo...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p>The plots are generated using parameters in <b><a href="http://www.plosone.org/article/info:doi/1...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p>(A) Average peak currents normalized to cell capacitance. Smooth curves represent fits to the ave...
<p>Full lines represent activation curves. Dashed lines represent inactivation curves. Time-constant...
<p><i>ρ</i> represents the postulated number of gates, <i>m</i><sub>∞</sub> is the steady-state acti...
<p>(<b>A–E</b>), typical superimposed current traces. The inset illustrates voltage protocol. The bl...
<p>A: Decay from peak of activation during a voltage-clamp of -10 mV in Nav 1.1 modelled channel. Th...
<p>In the first three rows, we illustrated the different electrophysiological features of the three ...
<p>(A) Steady-state activation as function of voltage. (B) Time constants of inactivation as functio...
<p>The graphs show the membrane potential of the PG cell model in response to a depolarizing current...
This study aimed to elucidate the mechanisms underlying the divergent action potential (AP) morpholo...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p>The plots are generated using parameters in <b><a href="http://www.plosone.org/article/info:doi/1...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p>(A) Average peak currents normalized to cell capacitance. Smooth curves represent fits to the ave...