Additional file 3: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Ming Zhang (9736)
Hua-Jin Pang (5167337)
Wei Zhao (14321)
Yu-Fa Li (5167340)
Li-Xu Yan (223343)
Zhong-Yi Dong (5167343)
Xiao-Feng He (456180)

Publication date

May 2018

DOI

10.6084/m9.figshare.6214418.v1

Abstract

Figure S2. Immunohistochemically staining of CD8 proteins in patients with hepatocellular carcinoma. Representative images of different density of CD8+ tumor infiltrating lymphocytes. (TIF 56816Â kb

Extracted data

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Data Protection

Additional file 3: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Ming Zhang (9736)
Hua-Jin Pang (5167337)
Wei Zhao (14321)
Yu-Fa Li (5167340)
Li-Xu Yan (223343)
Zhong-Yi Dong (5167343)
Xiao-Feng He (456180)

Open link

Publication date

May 2018

DOI

10.6084/m9.figshare.6214418.v1

Abstract

Figure S2. Immunohistochemically staining of CD8 proteins in patients with hepatocellular carcinoma. Representative images of different density of CD8+ tumor infiltrating lymphocytes. (TIF 56816Â kb

Extracted data

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S5. The expression of immune checkpoints on adoptively transferred TAA-specific CD8+ T cells....

Additional file 1: of Immune characterization of breast cancer metastases: prognostic implications

Maria Dieci (5437085)
Vassilena Tsvetkova (5437097)
Enrico Orvieto (5437064)
Federico Piacentini (5437088)
Guido Ficarra (2339788)
Gaia Griguolo (5042417)
Federica Miglietta (5437067)
Tommaso Giarratano (5437076)
Claudia Omarini (5437070)
Serena Bonaguro (5437094)
Rocco Cappellesso (384017)
Camillo Aliberti (703434)
Grazia Vernaci (5437073)
Carlo Giorgi (5437079)
Giovanni Faggioni (42109)
Giulia Tasca (5437091)
Pierfranco Conte (5437082)
Valentina Guarneri (3562331)

June 2018

Table S1. CD8 levels distribution according to tumor subtype and clinicopathological features. (DOCX...

Additional file 3: of PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

Wuhua Zhou (5719106)
Li Gong (205336)
Qinchuan Wu (5719109)
Chunyang Xing (3465299)
Bajin Wei (339581)
Tianchi Chen (5719112)
Yuan Zhou (179597)
Shengyong Yin (459720)
Bin Jiang (196018)
Haiyang Xie (187082)
Lin Zhou (141050)
Shusen Zheng (187083)

September 2018

Figure S1. Representative PHF8 IHC images with different stainingintensity. Magnification, Ă 40, Ă...

Additional file 2: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Ming Zhang (9736)
Hua-Jin Pang (5167337)
Wei Zhao (14321)
Yu-Fa Li (5167340)
Li-Xu Yan (223343)
Zhong-Yi Dong (5167343)
Xiao-Feng He (456180)

May 2018

Figure S1. Immunohistochemically staining of PD-L1 proteins in patients with hepatocellular carcinom...

Additional file 1: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Ming Zhang (9736)
Hua-Jin Pang (5167337)
Wei Zhao (14321)
Yu-Fa Li (5167340)
Li-Xu Yan (223343)
Zhong-Yi Dong (5167343)
Xiao-Feng He (456180)

May 2018

Table S1. Demographic and clinicopathologic characteristics of hepatocellular carcinoma samples in 2...

Additional file 3: of Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Keith Steele (4917040)
Tze Tan (4917055)
RenĂŠ Korn (4917088)
Karma Dacosta (4917043)
Charles Brown (40427)
Michael Kuziora (4917031)
Johannes Zimmermann (1743364)
Brian Laffin (4917037)
Moritz Widmaier (269049)
Lorenz Rognoni (4917049)
Ruben Cardenes (4917052)
Katrin Schneider (3039294)
Anmarie Boutrin (94563)
Philip Martin (377351)
Jiping Zha (4917034)
Tobias Wiestler (4917058)

March 2018

Figure S1 IA classification of CD8+ lymphocytes. Figure S2 IA classification of elongate CD8+ lympho...

Additional file 1: of Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Keith Steele (4917040)
Tze Tan (4917055)
RenĂŠ Korn (4917088)
Karma Dacosta (4917043)
Charles Brown (40427)
Michael Kuziora (4917031)
Johannes Zimmermann (1743364)
Brian Laffin (4917037)
Moritz Widmaier (269049)
Lorenz Rognoni (4917049)
Ruben Cardenes (4917052)
Katrin Schneider (3039294)
Anmarie Boutrin (94563)
Philip Martin (377351)
Jiping Zha (4917034)
Tobias Wiestler (4917058)

March 2018

Table S1 Relevant image information for nonclinical sample sets. Table S2 Nonclinical tumor samples,...

Additional file 2: of Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Keith Steele (4917040)
Tze Tan (4917055)
RenĂŠ Korn (4917088)
Karma Dacosta (4917043)
Charles Brown (40427)
Michael Kuziora (4917031)
Johannes Zimmermann (1743364)
Brian Laffin (4917037)
Moritz Widmaier (269049)
Lorenz Rognoni (4917049)
Ruben Cardenes (4917052)
Katrin Schneider (3039294)
Anmarie Boutrin (94563)
Philip Martin (377351)
Jiping Zha (4917034)
Tobias Wiestler (4917058)

March 2018

CD8/PD-L1 dual IHC, quality control; co-registration; details of the automated classification assess...

Additional file 7 of Multi-perspective comparison of the immune microenvironment of primary colorectal cancer and liver metastases

Yangsong He (13909371)
Yanan Han (2364166)
A-hui Fan (13909374)
Danxiu Li (12234857)
Boda Wang (13909377)
Kun Ji (1558783)
Xin Wang (91924)
Xiaodi Zhao (224410)
Yuanyuan Lu (13909380)

October 2022

Additional file 7: Figure S4. Comparison of the three immunotypes according to the degree of CD8 inf...

Additional file 2: of RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer

Fanny Ledys (5990285)
Quentin Klopfenstein (5990288)
Caroline Truntzer (397335)
Laurent Arnould (805607)
Julie Vincent (4738878)
Leila Bengrine (5434766)
Romain Remark (5990291)
Romain Boidot (190689)
Sylvain Ladoire (44718)
Francois Ghiringhelli (5654308)
Valentin Derangere (5990294)

November 2018

Figure S1. Immune parameters correlation. Figure S2. Impact of Ras-Raf mutationnal status tumor envi...

Additional file 6: of CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110Î˛ and predicts poor prognosis

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 4: Figure S2. of CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma

Li Li (14993)
Li Xu (108702)
Jing Yan (312090)
Zuo-Jun Zhen (642826)
Yong Ji (296783)
Chao-Qun Liu (642825)
Wan Lau (3485807)
Limin Zheng (385489)
Jing Xu (1234089)

October 2015

The number of CD15+, CD68+, CD3+, and S100+ cells in different regions of HCC tissues. Paraffin-embe...

Additional file 1: of Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer

Lisa König (3580973)
Fabian Mairinger (6279713)
Oliver Hoffmann (3580964)
Ann-Kathrin Bittner (3580961)
Kurt Schmid (3491198)
Rainer Kimmig (58539)
Sabine Kasimir-Bauer (3580967)
Agnes Bankfalvi (284668)

February 2019

Figure S1. Representative immunohistochemistry (IHC) staining images for CD8, CD4, CD20 and CD68. Im...

Additional file 1: of Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study

Minoru Miyashita (3561971)
Hironobu Sasano (368960)
Kentaro Tamaki (2440135)
Hisashi Hirakawa (3561962)
Yayoi Takahashi (3561968)
Saki Nakagawa (3561965)
Gou Watanabe (3561977)
Hiroshi Tada (822204)
Akihiko Suzuki (3561974)
Noriaki Ohuchi (360735)
Takanori Ishida (822205)

September 2015

The correlation diagrams of CD8 + TIL, FOXP3 + TIL, and CD8/FOXP3 ratio with residual cancer burden ...

Additional file 4: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S3. The expression of immune checkpoints on CD8+ T cells and CD4â+âT cells from mice rece...

Additional file 6: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S5. The expression of immune checkpoints on adoptively transferred TAA-specific CD8+ T cells....

Additional file 1: of Immune characterization of breast cancer metastases: prognostic implications

Maria Dieci (5437085)
Vassilena Tsvetkova (5437097)
Enrico Orvieto (5437064)
Federico Piacentini (5437088)
Guido Ficarra (2339788)
Gaia Griguolo (5042417)
Federica Miglietta (5437067)
Tommaso Giarratano (5437076)
Claudia Omarini (5437070)
Serena Bonaguro (5437094)
Rocco Cappellesso (384017)
Camillo Aliberti (703434)
Grazia Vernaci (5437073)
Carlo Giorgi (5437079)
Giovanni Faggioni (42109)
Giulia Tasca (5437091)
Pierfranco Conte (5437082)
Valentina Guarneri (3562331)

June 2018

Table S1. CD8 levels distribution according to tumor subtype and clinicopathological features. (DOCX...

Additional file 3: of PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

Wuhua Zhou (5719106)
Li Gong (205336)
Qinchuan Wu (5719109)
Chunyang Xing (3465299)
Bajin Wei (339581)
Tianchi Chen (5719112)
Yuan Zhou (179597)
Shengyong Yin (459720)
Bin Jiang (196018)
Haiyang Xie (187082)
Lin Zhou (141050)
Shusen Zheng (187083)

September 2018

Figure S1. Representative PHF8 IHC images with different stainingintensity. Magnification, Ă 40, Ă...

Additional file 2: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Ming Zhang (9736)
Hua-Jin Pang (5167337)
Wei Zhao (14321)
Yu-Fa Li (5167340)
Li-Xu Yan (223343)
Zhong-Yi Dong (5167343)
Xiao-Feng He (456180)

May 2018

Figure S1. Immunohistochemically staining of PD-L1 proteins in patients with hepatocellular carcinom...

Additional file 1: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Ming Zhang (9736)
Hua-Jin Pang (5167337)
Wei Zhao (14321)
Yu-Fa Li (5167340)
Li-Xu Yan (223343)
Zhong-Yi Dong (5167343)
Xiao-Feng He (456180)

May 2018

Table S1. Demographic and clinicopathologic characteristics of hepatocellular carcinoma samples in 2...

Additional file 3: of Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Keith Steele (4917040)
Tze Tan (4917055)
RenĂŠ Korn (4917088)
Karma Dacosta (4917043)
Charles Brown (40427)
Michael Kuziora (4917031)
Johannes Zimmermann (1743364)
Brian Laffin (4917037)
Moritz Widmaier (269049)
Lorenz Rognoni (4917049)
Ruben Cardenes (4917052)
Katrin Schneider (3039294)
Anmarie Boutrin (94563)
Philip Martin (377351)
Jiping Zha (4917034)
Tobias Wiestler (4917058)

March 2018

Figure S1 IA classification of CD8+ lymphocytes. Figure S2 IA classification of elongate CD8+ lympho...

Additional file 1: of Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Keith Steele (4917040)
Tze Tan (4917055)
RenĂŠ Korn (4917088)
Karma Dacosta (4917043)
Charles Brown (40427)
Michael Kuziora (4917031)
Johannes Zimmermann (1743364)
Brian Laffin (4917037)
Moritz Widmaier (269049)
Lorenz Rognoni (4917049)
Ruben Cardenes (4917052)
Katrin Schneider (3039294)
Anmarie Boutrin (94563)
Philip Martin (377351)
Jiping Zha (4917034)
Tobias Wiestler (4917058)

March 2018

Table S1 Relevant image information for nonclinical sample sets. Table S2 Nonclinical tumor samples,...

Additional file 2: of Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Keith Steele (4917040)
Tze Tan (4917055)
RenĂŠ Korn (4917088)
Karma Dacosta (4917043)
Charles Brown (40427)
Michael Kuziora (4917031)
Johannes Zimmermann (1743364)
Brian Laffin (4917037)
Moritz Widmaier (269049)
Lorenz Rognoni (4917049)
Ruben Cardenes (4917052)
Katrin Schneider (3039294)
Anmarie Boutrin (94563)
Philip Martin (377351)
Jiping Zha (4917034)
Tobias Wiestler (4917058)

March 2018

CD8/PD-L1 dual IHC, quality control; co-registration; details of the automated classification assess...

Additional file 7 of Multi-perspective comparison of the immune microenvironment of primary colorectal cancer and liver metastases

Yangsong He (13909371)
Yanan Han (2364166)
A-hui Fan (13909374)
Danxiu Li (12234857)
Boda Wang (13909377)
Kun Ji (1558783)
Xin Wang (91924)
Xiaodi Zhao (224410)
Yuanyuan Lu (13909380)

October 2022

Additional file 7: Figure S4. Comparison of the three immunotypes according to the degree of CD8 inf...

Additional file 2: of RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer

Fanny Ledys (5990285)
Quentin Klopfenstein (5990288)
Caroline Truntzer (397335)
Laurent Arnould (805607)
Julie Vincent (4738878)
Leila Bengrine (5434766)
Romain Remark (5990291)
Romain Boidot (190689)
Sylvain Ladoire (44718)
Francois Ghiringhelli (5654308)
Valentin Derangere (5990294)

November 2018

Figure S1. Immune parameters correlation. Figure S2. Impact of Ras-Raf mutationnal status tumor envi...

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 4: Figure S2. of CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma

Li Li (14993)
Li Xu (108702)
Jing Yan (312090)
Zuo-Jun Zhen (642826)
Yong Ji (296783)
Chao-Qun Liu (642825)
Wan Lau (3485807)
Limin Zheng (385489)
Jing Xu (1234089)

October 2015

The number of CD15+, CD68+, CD3+, and S100+ cells in different regions of HCC tissues. Paraffin-embe...

Lisa König (3580973)
Fabian Mairinger (6279713)
Oliver Hoffmann (3580964)
Ann-Kathrin Bittner (3580961)
Kurt Schmid (3491198)
Rainer Kimmig (58539)
Sabine Kasimir-Bauer (3580967)
Agnes Bankfalvi (284668)

February 2019

Figure S1. Representative immunohistochemistry (IHC) staining images for CD8, CD4, CD20 and CD68. Im...

Minoru Miyashita (3561971)
Hironobu Sasano (368960)
Kentaro Tamaki (2440135)
Hisashi Hirakawa (3561962)
Yayoi Takahashi (3561968)
Saki Nakagawa (3561965)
Gou Watanabe (3561977)
Hiroshi Tada (822204)
Akihiko Suzuki (3561974)
Noriaki Ohuchi (360735)
Takanori Ishida (822205)

September 2015

The correlation diagrams of CD8 + TIL, FOXP3 + TIL, and CD8/FOXP3 ratio with residual cancer burden ...

Additional file 4: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S3. The expression of immune checkpoints on CD8+ T cells and CD4â+âT cells from mice rece...

Additional file 6: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S5. The expression of immune checkpoints on adoptively transferred TAA-specific CD8+ T cells....

Additional file 1: of Immune characterization of breast cancer metastases: prognostic implications

Maria Dieci (5437085)
Vassilena Tsvetkova (5437097)
Enrico Orvieto (5437064)
Federico Piacentini (5437088)
Guido Ficarra (2339788)
Gaia Griguolo (5042417)
Federica Miglietta (5437067)
Tommaso Giarratano (5437076)
Claudia Omarini (5437070)
Serena Bonaguro (5437094)
Rocco Cappellesso (384017)
Camillo Aliberti (703434)
Grazia Vernaci (5437073)
Carlo Giorgi (5437079)
Giovanni Faggioni (42109)
Giulia Tasca (5437091)
Pierfranco Conte (5437082)
Valentina Guarneri (3562331)

June 2018

Table S1. CD8 levels distribution according to tumor subtype and clinicopathological features. (DOCX...

Additional file 3: of PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

Wuhua Zhou (5719106)
Li Gong (205336)
Qinchuan Wu (5719109)
Chunyang Xing (3465299)
Bajin Wei (339581)
Tianchi Chen (5719112)
Yuan Zhou (179597)
Shengyong Yin (459720)
Bin Jiang (196018)
Haiyang Xie (187082)
Lin Zhou (141050)
Shusen Zheng (187083)

September 2018

Figure S1. Representative PHF8 IHC images with different stainingintensity. Magnification, Ă 40, Ă...

Additional file 3: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Abstract

Extracted data

Additional file 3: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Abstract

Extracted data

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