Additional file 4: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

Publication date

December 2018

DOI

10.6084/m9.figshare.7440026.v1

Abstract

Figure S3. The expression of immune checkpoints on CD8+ T cells and CD4â+âT cells from mice receiving HDI of pKT2/CLP-AKT-Ags-LUC, pT/Caggs-NRASV12 and pCMV(CAT)T7-SB100. (PDF 313 kb

Extracted data

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Additional file 4: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

Open link

Publication date

December 2018

DOI

10.6084/m9.figshare.7440026.v1

Abstract

Figure S3. The expression of immune checkpoints on CD8+ T cells and CD4â+âT cells from mice receiving HDI of pKT2/CLP-AKT-Ags-LUC, pT/Caggs-NRASV12 and pCMV(CAT)T7-SB100. (PDF 313 kb

Extracted data

Fen Xu (326364)
Junli Liu (240401)
Jie Deng (190312)
Xiaolei Chen (2360686)
Yuan Wang (14955)
Pengchao Xu (3554312)
Lin Cheng (107461)
Yanli Fu (3554315)
Fuyi Cheng (3554309)
Yunqi Yao (3554318)
Yujing Zhang (385508)
Meijuan Huang (3554321)
Dechao Yu (3068661)
Yuquan Wei (267570)
Hongxin Deng (3554306)

October 2015

Showing transplantation of iHeps into BALB/c nude mice, related to Fig. 4. HepG2 (1 × 106) or iHeps ...

Additional file 6: of CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110Î˛ and predicts poor prognosis

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 1: of Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma

Ian Lai (5998268)
Srividya Swaminathan (3110526)
Virginie Baylot (5998271)
Adriane Mosley (5998274)
Renumathy Dhanasekaran (5998277)
Meital Gabay (5998280)
Dean Felsher (79841)

November 2018

IL-12-LNP does not induce toxicity in healthy mice. (a) Evaluation of toxicity of IL-12 oligonucleot...

Additional file 6: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S5. The expression of immune checkpoints on adoptively transferred TAA-specific CD8+ T cells....

Additional file 5: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S4. Proliferation and cytokine production of intra-tumoral and splenic CD8+ and CD4+ T cells ...

Additional file 3: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S2. Characterization of OVA257-264-specific CTLs in HCC tumor microenvironment. (PDF 367 kb

Additional file 1: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Table S1. List of antibodies used in immunohistochemistry and in flow cytometry. (PDF 37 kb

Additional file 1: of Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background

Sook Chung (3425123)
Hyuk Moon (3425129)
Dae Kim (305795)
Kyung Cho (3425117)
Hye-Lim Ju (395738)
Do Kim (3425114)
Sang Ahn (3425126)
Kwang-Hyub Han (131978)
Simon Ro (3425120)

January 2016

Histological analysis of livers harvested at 15 days post hydrodynamic transfection with transposons...

Additional file 1: of Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

May Saung (5961734)
Stephen Muth (5961737)
Ding Ding (346784)
Dwayne Thomas (5961740)
Alex Blair (5961743)
Takahiro Tsujikawa (5809061)
Lisa Coussens (714916)
Elizabeth Jaffee (2029204)
Lei Zheng (106363)

November 2018

Figure S1. PD-1 expression on CD4+ and CD8+ T-cells can increase with the addition of αCSF-1R to GVA...

Additional file 2: of Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma

Ian Lai (5998268)
Srividya Swaminathan (3110526)
Virginie Baylot (5998271)
Adriane Mosley (5998274)
Renumathy Dhanasekaran (5998277)
Meital Gabay (5998280)
Dean Felsher (79841)

November 2018

HCC clearance by IL-12-LNP is associated with anti-tumor immunological changes. (a-b) Splenic weight...

Additional file 1: of Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Stefanie Wculek (6566330)
JoaquĂn Amores-Iniesta (6566342)
Ruth Conde-Garrosa (6566336)
SofĂa Khouili (6566345)
Ignacio Melero (81908)
David Sancho (5117801)

April 2019

Figure S1. Isolation and phenotypic analysis of cDC1s from the spleen of FLT3L-expressing B16 tumor-...

Additional file 1: of Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4+ T cells in mice

Yanzhen Bi (6200753)
Jiannan Li (1505440)
Yonghong Yang (428510)
Quanyi Wang (296707)
Quanquan Wang (3196311)
Xiaobei Zhang (4730490)
Guanjun Dong (5966684)
Yibo Wang (304377)
Zhongping Duan (304742)
Zhenfeng Shu (6200756)
Tongjun Liu (449137)
Yu Chen (29959)
Kai Zhang (102844)
Feng Hong (174976)

January 2019

Biochemical evaluation in the serum and the detection of tracing of transplanted cells. Supplementar...

Additional file 3: of Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models

Roberto Rosato (5722406)
Daniel Dávila-González (5722409)
Dong Choi (3578132)
Wei Qian (56612)
Wen Chen (30046)
Anthony Kozielski (5722412)
Helen Wong (241565)
Bhuvanesh Dave (147341)
Jenny Chang (3489839)

September 2018

IHC analysis of human CD4-, CD3-, CD8-, CD20-, CD68-, CD4-, and CD8-positive cells present in BCM-21...

Additional file 4: Figure S2. of Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol

Fen Xu (326364)
Junli Liu (240401)
Jie Deng (190312)
Xiaolei Chen (2360686)
Yuan Wang (14955)
Pengchao Xu (3554312)
Lin Cheng (107461)
Yanli Fu (3554315)
Fuyi Cheng (3554309)
Yunqi Yao (3554318)
Yujing Zhang (385508)
Meijuan Huang (3554321)
Dechao Yu (3068661)
Yuquan Wei (267570)
Hongxin Deng (3554306)

October 2015

Showing transplantation of iHeps into BALB/c nude mice, related to Fig. 4. HepG2 (1 × 106) or iHeps ...

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 1: of Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma

Ian Lai (5998268)
Srividya Swaminathan (3110526)
Virginie Baylot (5998271)
Adriane Mosley (5998274)
Renumathy Dhanasekaran (5998277)
Meital Gabay (5998280)
Dean Felsher (79841)

November 2018

IL-12-LNP does not induce toxicity in healthy mice. (a) Evaluation of toxicity of IL-12 oligonucleot...

Additional file 6: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S5. The expression of immune checkpoints on adoptively transferred TAA-specific CD8+ T cells....

Additional file 5: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S4. Proliferation and cytokine production of intra-tumoral and splenic CD8+ and CD4+ T cells ...

Additional file 3: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Figure S2. Characterization of OVA257-264-specific CTLs in HCC tumor microenvironment. (PDF 367 kb

Additional file 1: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Yu-Tzu Liu (1611097)
Tai-Chung Tseng (289147)
Ruey-Shyang Soong (182059)
Chun-Yi Peng (6062759)
Yu-Hsing Cheng (6062765)
Shiu-Feng Huang (442981)
Tsung-Hsien Chuang (194787)
Jia-Horng Kao (85991)
Li-Rung Huang (704616)

December 2018

Table S1. List of antibodies used in immunohistochemistry and in flow cytometry. (PDF 37 kb

Additional file 1: of Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background

Sook Chung (3425123)
Hyuk Moon (3425129)
Dae Kim (305795)
Kyung Cho (3425117)
Hye-Lim Ju (395738)
Do Kim (3425114)
Sang Ahn (3425126)
Kwang-Hyub Han (131978)
Simon Ro (3425120)

January 2016

Histological analysis of livers harvested at 15 days post hydrodynamic transfection with transposons...

Additional file 1: of Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

May Saung (5961734)
Stephen Muth (5961737)
Ding Ding (346784)
Dwayne Thomas (5961740)
Alex Blair (5961743)
Takahiro Tsujikawa (5809061)
Lisa Coussens (714916)
Elizabeth Jaffee (2029204)
Lei Zheng (106363)

November 2018

Figure S1. PD-1 expression on CD4+ and CD8+ T-cells can increase with the addition of αCSF-1R to GVA...

Additional file 2: of Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma

Ian Lai (5998268)
Srividya Swaminathan (3110526)
Virginie Baylot (5998271)
Adriane Mosley (5998274)
Renumathy Dhanasekaran (5998277)
Meital Gabay (5998280)
Dean Felsher (79841)

November 2018

HCC clearance by IL-12-LNP is associated with anti-tumor immunological changes. (a-b) Splenic weight...

Additional file 1: of Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Stefanie Wculek (6566330)
JoaquĂn Amores-Iniesta (6566342)
Ruth Conde-Garrosa (6566336)
SofĂa Khouili (6566345)
Ignacio Melero (81908)
David Sancho (5117801)

April 2019

Figure S1. Isolation and phenotypic analysis of cDC1s from the spleen of FLT3L-expressing B16 tumor-...

Additional file 1: of Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4+ T cells in mice

Yanzhen Bi (6200753)
Jiannan Li (1505440)
Yonghong Yang (428510)
Quanyi Wang (296707)
Quanquan Wang (3196311)
Xiaobei Zhang (4730490)
Guanjun Dong (5966684)
Yibo Wang (304377)
Zhongping Duan (304742)
Zhenfeng Shu (6200756)
Tongjun Liu (449137)
Yu Chen (29959)
Kai Zhang (102844)
Feng Hong (174976)

January 2019

Biochemical evaluation in the serum and the detection of tracing of transplanted cells. Supplementar...

Additional file 3: of Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models

Roberto Rosato (5722406)
Daniel Dávila-González (5722409)
Dong Choi (3578132)
Wei Qian (56612)
Wen Chen (30046)
Anthony Kozielski (5722412)
Helen Wong (241565)
Bhuvanesh Dave (147341)
Jenny Chang (3489839)

September 2018

IHC analysis of human CD4-, CD3-, CD8-, CD20-, CD68-, CD4-, and CD8-positive cells present in BCM-21...

Additional file 4: Figure S2. of Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol

Fen Xu (326364)
Junli Liu (240401)
Jie Deng (190312)
Xiaolei Chen (2360686)
Yuan Wang (14955)
Pengchao Xu (3554312)
Lin Cheng (107461)
Yanli Fu (3554315)
Fuyi Cheng (3554309)
Yunqi Yao (3554318)
Yujing Zhang (385508)
Meijuan Huang (3554321)
Dechao Yu (3068661)
Yuquan Wei (267570)
Hongxin Deng (3554306)

October 2015

Showing transplantation of iHeps into BALB/c nude mice, related to Fig. 4. HepG2 (1 × 106) or iHeps ...

Xiao-Lu Ma (4175050)
Min-Na Shen (6578531)
Bo Hu (126105)
Bei-Li Wang (6578534)
Wen-Jing Yang (6578537)
Li-Hua Lv (6578540)
Hao Wang (39217)
Yan Zhou (6523)
An-Li Jin (6578543)
Yun-Fan Sun (6578546)
Chuan-Yan Zhang (6578549)
Shuang-Jian Qiu (157512)
Bai-Shen Pan (4175047)
Jian Zhou (28020)
Jia Fan (178422)
Xin-Rong Yang (202583)
Wei Guo (86150)

April 2019

Figure S5. In vivo function of CD73 in HCC. (A) Representative IHC images of PCNA expression level i...

Additional file 1: of Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma

Ian Lai (5998268)
Srividya Swaminathan (3110526)
Virginie Baylot (5998271)
Adriane Mosley (5998274)
Renumathy Dhanasekaran (5998277)
Meital Gabay (5998280)
Dean Felsher (79841)

November 2018

IL-12-LNP does not induce toxicity in healthy mice. (a) Evaluation of toxicity of IL-12 oligonucleot...

Additional file 4: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Abstract

Extracted data

Additional file 4: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Abstract

Extracted data

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