A computational study of astrocytic glutamate influence on post-synaptic neuronal excitability - Fig 8

<p><b>Postsynaptic activity due to synaptic and intrinsic currents</b>, triggered by (a) synaptic glutamate [Glu]_syn (b-d) simulation with [Glu]_ast,eq = 1.5mM, 5mM, and 10mM respectively, synaptic currents (I_syn) combined AMPA- and NMDA-mediated currents in response to synaptic glutamate, membrane potential (V_m) of postsynaptic neuron resulting from combination of I_syn and voltage-gated currents (Na⁺, K⁺ and leak). Prolonged time course of synaptic glutamate leads to enhanced synaptic currents (I_syn) and higher frequency postsynaptic firing response (V_m depolarisations) as [Glu]_ast,eq increases.