Additional file 9: of Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
- Matthew Garrett (2652571)
- Jantzen Sperry (5119271)
- Daniel Braas (80410)
- Weihong Yan (2358406)
- Thuc Le (1344843)
- Jack Mottahedeh (5119268)
- Kirsten Ludwig (5119265)
- Ascia Eskin (253930)
- Yue Qin (634751)
- Rachelle Levy (5119274)
- Joshua Breunig (5119277)
- Frank Pajonk (59951)
- Thomas Graeber (4218709)
- Caius Radu (3400175)
- Heather Christofk (3452684)
- Robert Prins (5119259)
- Albert Lai (73635)
- Linda Liau (73631)
- Giovanni Coppola (46572)
- Harley Kornblum (5119262)
Publication date
April 2018
DOIAbstract
IDH1 mutant enzyme does not affect glucose labeling of nucleotide precursors. Cells were treated and analyzed as described for Supporting Figure S4 in order to determine the percent labeling of nucleotide precursors. There is no significant difference when comparing IDH1 mutant overexpression or endogenous mutant inhibition to their respective controls. (PDF 64Â kb
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