Additional file 8: of Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
- Matthew Garrett (2652571)
- Jantzen Sperry (5119271)
- Daniel Braas (80410)
- Weihong Yan (2358406)
- Thuc Le (1344843)
- Jack Mottahedeh (5119268)
- Kirsten Ludwig (5119265)
- Ascia Eskin (253930)
- Yue Qin (634751)
- Rachelle Levy (5119274)
- Joshua Breunig (5119277)
- Frank Pajonk (59951)
- Thomas Graeber (4218709)
- Caius Radu (3400175)
- Heather Christofk (3452684)
- Robert Prins (5119259)
- Albert Lai (73635)
- Linda Liau (73631)
- Giovanni Coppola (46572)
- Harley Kornblum (5119262)
Publication date
April 2018
DOIAbstract
IDH1 mutant overexpression leads to high levels of 2-HG and the c227 inhibitor is an effective inhibitor of 2-HG formation. IDH wildtype gliomaspheres transduced with the IDH1 mutant enzyme (308 + IDH1mut) and endogenous IDH1 mutant cells treated with 5 μM c227 inhibitor (213 + c227) for 24 h are compared to their respective controls (308 and 213) for 2-HG levels as determined by LC-MS. Data represent the means ± SEM of three replicates per condition. (PDF 22 kb
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