Examples of fitting of the Hermite, DoG-L7 and DoG-L8 models to smoothed and non-smoothed real vessel profiles.

<p>Profiles from 11 adjacent profiles are used. Black dots: profile data points; orange curve: fitted curve through Trust-Region-Reflective method; vertical yellow line: center of the profile; vertical purple lines: ground truth. <b>A</b>: original data, Hermite model (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0194702#pone.0194702.e003" target="_blank">Eq 1</a>); <b>B</b>: original data, DoG-L7 model (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0194702#pone.0194702.e005" target="_blank">Eq 3</a>); <b>C</b>: original data, DoG-L8 model (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0194702#pone.0194702.e006" target="_blank">Eq 4</a>); <b>D</b>: smoothed data, Hermite model; <b>E</b>: smoothed data, DoG-L7 model; <b>F</b>: smoothed data, DoG-L8 model.