Neutralization sensitivity of infant T/F pseudoviruses to a panel of bNAbs.

<p>The potency of the responses is color coded from dark to light where darker colors indicate stronger responses. Shades of red are used for infant responses, shades of green for potency, and shades of blue for breadth (% neutralization). Gray boxes indicate absence of response. The potency (geometric mean of responses) and breadth (% neutralized) of the infant viruses to each bNAb were compared with the geometric means of the bNAb’s potency and breadth obtained from published studies using the LANL repository CATNAP (columns on the right). The most potent neutralization against infant viruses was mediated by V3 glycan bNAbs and CD4 binding site specific NIH45-46.