Interplay of bnAb features that shape neutralization potency.

<p>Differential features shape the neutralization activity of bnAbs. Two main reactivity patterns can be observed: (i) BnAbs with high potency against free virus spread and high pre-attachment activity. (ii) BnAbs with lower efficacy against free virus spread, decreased pre-attachment but high post-CD4 attachment activity and retained activity during cell-cell transmission.