A twin study of genetic and environmental influences on relationship between attention deficit and anxiety/depression in children and adolescents

目的 探讨遗传和环境因素对儿童青少年注意问题和焦虑/抑郁关联的影响.方法 对1 062名同性别6～18岁双生子,采用Achenbach儿童行为量表家长用问卷进行调查.使用Mx软件拟合结构方程的单变量模型.构建Cholesky分解模型分析注意问题和焦虑/抑郁中的遗传和环境影响相关.结果 注意问题与焦虑/抑郁有遗传相关(rg=0.48),共享环境因素相关作用为0.86,非共享环境因素相关作用为0.14.结论 遗传因素和共享环境因素对注意问题和焦虑/抑郁的相关起重要作用,非共享环境因素对相关所起作用较小.Objective To understand the genetic and environmental influences on the relationship between attention deficit and anxiety/depression in children and adolescents.Methods A total of 1 062 same-sex twins aged 6-18 years were included in this study.A parent-rated child behavior checklist (CBCL) was used in the assessment.Software Mx was used to fit the univariate model of structural equation.The relationship between attention deficit and anxiety/depression was analyzed through bivariate genetic modeling.Results The genetic factor had influence on the relationship between attention deficit and anxiety/depression (rg=0.48).Shared and non-shared environmental correlation scores of attention deficit and anxiety/depression were 0.86 and 0.14 respectively.Conclusion Common genetic and shared environmental influences can explain the relationship between attention deficit and anxiety/depression in children and adolescents.国家自然科学基金(81001249)National Natural Science Foundation of China91183-11863