Association of serum uric acid level with amyotrophic lateral sclerosis

目的：探讨血清尿酸（ UA）水平与肌萎缩侧索硬化症（ ALS）的关系。方法检测2010年1月至2014年12月北京大学第三医院门诊和住院164例ALS患者和164名性别、年龄匹配的健康体检者的血清尿酸（ UA）、肌酐（ Cr）和尿素氮（ BUN）水平，比较两组间的差异。结果 ALS患者血清UA水平明显低于健康对照组[（310±88）μmol／L 比（356±78）μmol／L，P＜0．01]，按照性别分组后差异仍有统计学意义（ P＜0．01）。 Logistic回归显示UA水平与ALS相关，是重要的危险因素。按照修订版神经功能评分（ ALSFRS－R）总分和ALSFRS－R的线性变化率（ΔFS）分组，ALS患者血清UA水平差异无统计学意义（ P＞0．05）。结论 ALS患者血清UA显著低于健康对照组。血清UA水平与ALS病情严重程度、病程进展速度无关。Objective To investigate the association between the serum uric acid ( UA) level and amyotrophic lateral sclerosis(ALS).Methods The serum UA levels were measured from 164 ALS patients and 164 gender and age matched controls.The serum creatinine ( Cr) and blood urea nitrogen ( BUN) levels were also measured to reduce the bias caused by possible differences in renal excretion function.The differences of the above indexes were compared between the two groups.Results The serum UA levels in ALS patients were lower than those in healthy controls ((310 ±88) μmol/L vs (356 ±78) μmol/L, P<0.01) .The differences were observed in both genders.In a Logistic regression model using ALS as a dependent variable,the serum UA level was significantly associated with ALS.The differences of the serum UA levels in ALS patients stratified by the revised ALS functional rating scale ( ALSFRS-R ) and the progression rate of ALSFRS-R (ΔFS ) were not statistically significant ( P >0.05 ) .Conclusions ALS patients are found to have significantly lower serum UA levels than healthy individuals.The serum UA level is not involved in disease severity and progression.PubMed中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)3207-2099