Serum uric acid levels in patients with multiple system atrophy

目的 探讨多系统萎缩患者血清尿酸水平及其与病情严重程度的相关性.方法 连续选取2012-06-2016-12在北京大学深圳医院神经内科就诊的多系统萎缩患者32例,详细进行病史采集及体格检查,并进行统一多系统萎缩评估量表(UMSARS)评估.另选择同期健康体检者50例为健康对照组,2组均测定空腹血清尿酸水平.结果 MSA-P组及MSA-C组的尿酸水平均低于对照组,差异有统计学意义(P<0.05);MSA-P组血清尿酸水平与MSA-C组比较,差异无统计学意义(P>0.05);MSA患者尿酸水平与UMSARS评分呈负相关(Pearson r=-0.389,P<0.05),但与病程年限无相关性(P>0.05).结论 MSA患者血清尿酸水平降低,低尿酸可能与MSA发病有关;尿酸与MSA病情严重程度呈负相关.Objective To explore the levels of serum uric acid and its relationship with the disease severity in patients with multiple system atrophy (MSA).Methods We consecutively selected 32 MSA patients in Shenzhen Hospital Affiliated to Peking University from June 2012 to December 2016.Detailed history taking and physical examination were executed for each patient,and the unified multiple system atrophy rating scale (UMSARS) was used.All of 50 healthy cases were selected as control group.Fasting serum uric acid levels of two groups were compared.Results The levels of serum uric acid in MSA-P group and MSA-C group were lower than those in the control group (P<0.05),but there was no difference between MSA-P group and MSA-C group (P>0.05).In the MSA group,the levels of serum uric acid had a negative correlation with UMSARS scores (Pearson r=-0.389,P<0.05),but had no relationship with illness duration (P>0.05).Conclusion The low levels of serum uric acid may be related to the occurrence of MSA and to some extent have a negative correlation with disease severity of MSA.深圳市科技研发基金1215-172