Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer-Type Transformation

Wang, Xi
Xu, Yan
Zhou, Yujing
Zhang, Yan
Wang, Jianbo

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Publication date

January 2014

DOI

10.1055/s-0033-1338659

Publisher

synthesis stuttgart

ISSN

0039-7881

Journal

issn:0039-7881

Citation count (estimate)

Abstract

A novel strategy for aromatic trifluoromethylation by converting amino into trifluoromethyl groups via a Sandmeyer-type reaction is reported. The transformation involves diazotization of the aromatic amines with tert-butyl nitrite and hydrochloric acid to form aryldiazonium chlorides, followed by trifluoromethylation with trifluoromethylsilver at low temperature. Various readily available aromatic amines are smoothly converted under mild conditions.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000340875300004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Chemistry, OrganicSCI(E)4ARTICLEwangjb@pku.edu.cn162143-21484

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Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer-Type Transformation

Abstract

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Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer-Type Transformation

Abstract

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