Increased interest in the trifluoromethoxy group in organic synthesis and medicinal chemistry has induced a demand for new, selective, general, and faster methods applicable to natural products and highly functionalized compounds at a later stage of hit-to-lead campaigns. Applying pyrylium tetrafluoroborate, we have developed a mechanochemical protocol to selectively substitute the aromatic amino group with the OCF3functionality. The scope of our method includes 31 examples of ring-substituted anilines, including amides and sulfonamides. Expected SNAr products were obtained in excellent yields. The presented concise method opens a pathway to new chemical spaces for the pharmaceutical industry.This research is supported by a grant from Natio...
Funding: UK Engineering and Physical Sciences Research Council - EP/S030506/1; Commonwealth Scholars...
Fluorinated organic compounds have received great attention and even play a key role in human daily ...
Fluorine-containing organic scaffolds are of significant interest in medicinal chemistry. The incorp...
Increased interest in the trifluoromethoxy group in organic synthesis and medicinal chemistry has in...
Fluorinated substances have outstanding importance in most fields of the chemical industry, from ag...
The amide bond is prominent in natural and synthetic organic molecules endowed with activity in vari...
Using organofluorine molecules in medicinal chemistry has become commonplace in recent times, not ju...
The two-step preparation of triazenes from commercially available anilines using a continuous-flow t...
Within the past few decades, the presence of fluorine containing organic molecules has increased sig...
The Royal Society is thanked for support through its Wolfson Research Merit Award Scheme (DO’H).Sele...
Chapter 1 — Triarylmethanes by the Truce–Smiles rearrangement of benzanilidesThe triarylmethane (TRA...
We communicate two mild, solvent-free mechanochemical coupling transformations of CF3 group with nit...
Per- and polyfluoroarenes are important synthetic chemistry targets because they are active componen...
This thesis is concerned with new methodology for the introduction of fluorine atoms, and trifluorom...
Amines are a fundamentally important class of biologically active compounds and the ability to manip...
Funding: UK Engineering and Physical Sciences Research Council - EP/S030506/1; Commonwealth Scholars...
Fluorinated organic compounds have received great attention and even play a key role in human daily ...
Fluorine-containing organic scaffolds are of significant interest in medicinal chemistry. The incorp...
Increased interest in the trifluoromethoxy group in organic synthesis and medicinal chemistry has in...
Fluorinated substances have outstanding importance in most fields of the chemical industry, from ag...
The amide bond is prominent in natural and synthetic organic molecules endowed with activity in vari...
Using organofluorine molecules in medicinal chemistry has become commonplace in recent times, not ju...
The two-step preparation of triazenes from commercially available anilines using a continuous-flow t...
Within the past few decades, the presence of fluorine containing organic molecules has increased sig...
The Royal Society is thanked for support through its Wolfson Research Merit Award Scheme (DO’H).Sele...
Chapter 1 — Triarylmethanes by the Truce–Smiles rearrangement of benzanilidesThe triarylmethane (TRA...
We communicate two mild, solvent-free mechanochemical coupling transformations of CF3 group with nit...
Per- and polyfluoroarenes are important synthetic chemistry targets because they are active componen...
This thesis is concerned with new methodology for the introduction of fluorine atoms, and trifluorom...
Amines are a fundamentally important class of biologically active compounds and the ability to manip...
Funding: UK Engineering and Physical Sciences Research Council - EP/S030506/1; Commonwealth Scholars...
Fluorinated organic compounds have received great attention and even play a key role in human daily ...
Fluorine-containing organic scaffolds are of significant interest in medicinal chemistry. The incorp...