目的:研究神经病理性痛大鼠背根神经节(dorsal root ganglion, DRG)细胞电生理特征的改变.方法:以单侧L5和L6脊神经结扎制备大鼠神经病理性痛模型,运用全细胞电流钳技术进行电生理记录.结果:引起损伤侧DGR中、小直径神经元兴奋的基强度降低,动作电位爆发阈值下降,小直径神经元的动作电位时程变宽,自发放电的细胞比率明显升高.结论:神经损伤诱导初级感觉神经元的兴奋性增强,这可能是引起动物神经病理性痛敏的原因之一.国家重点基础研究发展计划(973计划); 国家自然科学基金中国科学引文数据库(CSCD)0131-34
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
AbstractPartial nerve injury leads to peripheral neuropathic pain. This injury results in conducting...
动作电位的异常爆发和编码是痛觉信号传递的电生理学基础.越来越多的证据表明,外周感觉神经元的敏化是慢性痛发生的重要机制之一.本次实验通过结扎大鼠单侧L5和L6脊神经诱发神经源性痛,经Von Frey H...
目的:研究超极化激活电流( hyperpolarization-activated current, Ih )在慢性神经源性痛中的作用.方法:以单侧L5和L6脊神经结扎制备神经源性痛大鼠模型,运用全细...
Background: The neuropathic pain induced by peripheral nerve injury has been shown to be spontaneous...
目的：以骨癌痛大鼠为例，探讨全细胞膜片钳技术在慢性痛研究中的应用。方法：急性分离背根神经节（dorsal root ganglion, DRG）神经元，利用全细胞膜片钳技术分别记录对照组和骨癌痛组大鼠...
目的:探讨应用肌电图行大鼠腰神经后根节段定位的方法.方法:通过电生理的方法,依次电刺激L3～L5脊神经后根,分别记录大鼠双侧下肢主要肌肉的肌电图像,测量最早出现的感觉神经动作电位(SNAP)最大波幅值...
目的:观察电压门控钠通道NaN/SNS2在大鼠坐骨神经慢性压迫性损伤(chronic constrictioninjupy,CCI)14天后的变化,探讨慢性神经痛的发生机制.方法:以逆转录多聚酶链反应...
The hyperpolarization-activated current (Ih) has been implicated in nociception/pain, but its expres...
科学研究費補助金研究成果報告書研究種目: 若手研究(B)研究期間: 2008～2009課題番号: 20791068研究代表者: J.P. Bellier（滋賀医科大学・分子神経科学研究センター・助教）...
目的:研究腰5脊神经结扎(L5 spinal nerve ligation,SNL)神经病理痛大鼠腰4背根神经节(dorsal root ganglion,DRG)神经元超极化激活电流(Ih)及其通道...
Peripheral nerve injury causes ectopic discharges of different firing patterns, which may play an im...
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
AbstractPartial nerve injury leads to peripheral neuropathic pain. This injury results in conducting...
动作电位的异常爆发和编码是痛觉信号传递的电生理学基础.越来越多的证据表明,外周感觉神经元的敏化是慢性痛发生的重要机制之一.本次实验通过结扎大鼠单侧L5和L6脊神经诱发神经源性痛,经Von Frey H...
目的:研究超极化激活电流( hyperpolarization-activated current, Ih )在慢性神经源性痛中的作用.方法:以单侧L5和L6脊神经结扎制备神经源性痛大鼠模型,运用全细...
Background: The neuropathic pain induced by peripheral nerve injury has been shown to be spontaneous...
目的：以骨癌痛大鼠为例，探讨全细胞膜片钳技术在慢性痛研究中的应用。方法：急性分离背根神经节（dorsal root ganglion, DRG）神经元，利用全细胞膜片钳技术分别记录对照组和骨癌痛组大鼠...
目的:探讨应用肌电图行大鼠腰神经后根节段定位的方法.方法:通过电生理的方法,依次电刺激L3～L5脊神经后根,分别记录大鼠双侧下肢主要肌肉的肌电图像,测量最早出现的感觉神经动作电位(SNAP)最大波幅值...
目的:观察电压门控钠通道NaN/SNS2在大鼠坐骨神经慢性压迫性损伤(chronic constrictioninjupy,CCI)14天后的变化,探讨慢性神经痛的发生机制.方法:以逆转录多聚酶链反应...
The hyperpolarization-activated current (Ih) has been implicated in nociception/pain, but its expres...
科学研究費補助金研究成果報告書研究種目: 若手研究(B)研究期間: 2008～2009課題番号: 20791068研究代表者: J.P. Bellier（滋賀医科大学・分子神経科学研究センター・助教）...
目的:研究腰5脊神经结扎(L5 spinal nerve ligation,SNL)神经病理痛大鼠腰4背根神经节(dorsal root ganglion,DRG)神经元超极化激活电流(Ih)及其通道...
Peripheral nerve injury causes ectopic discharges of different firing patterns, which may play an im...
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
Background and Objective The sensory cell somata in the DRG contain all equipment necessary for exte...
AbstractPartial nerve injury leads to peripheral neuropathic pain. This injury results in conducting...
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