It is generally believed that moral reductionism is immune from notorious problems in moral metaphysics and epistemology, such as the problem of moral explanation - it is at least on this dimension that moral reductionism scores better than moral anti-reductionism. However, in this article I reject this popular view. First, I argue that moral reductionism fails to help vindicate the explanatory efficacy of moral properties because the reductionist solution is either circular or otiose. Second, I attempt to show that a successful vindication, if any, of moral explanation requires moral-descriptive irreducibility. My discussion thus raises an explanatory challenge to moral reductionism