Because it is involved in the production of a wide range of added-value chemicals, methanol is one of the most important compounds in the industrial chemistry field. The significant thermodynamic limitations related to methanol synthesis via syngas conversion has intensified interest in this process. Starting with the development of the BASF process at the beginning of the 20th century and the ICI process, introduced in the 1960s, many schemes have been proposed for the overall optimization of the process. This chapter aims to explore the methanol synthesis process and the most relevant technologies available in the methanol industry