Safety of the recent oral lyophilisate formulation (MELT) in pediatric patients - A review
- Ferrara, P. (ORCID:0000-0001-9449-3464)
- Ianniello, F.
- Gatto, A.
- Ruggiero, A. (ORCID:0000-0002-6052-3511)
DOIAbstract
To review the safety of the recent oral lyophilisate formulation of desmopressin (MELT) in the pharmacological therapy for nocturnal enuresis (NE) and diabetes insipidus in pediatric patients. We searched for published reviews and references from PubMed- MEDLINE, Embase, and CENTRAL and did also a new search spanning the period Jan 1, 2000, until July 31, 2017 by using the terms MELT enuresis, MELT desmopressin, sublingual desmopressin, lyophilisate desmopressin. We evaluated all studies about side effects and effectiveness of MELT in pediatric patients.Twelve articles were analyzed with 1275 pediatric patients (<18 years old). The indication was enuresis in 1269 patients and central diabetes insipidus in 6 patients. In 11 studies desmopres...
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