In HFD mice, apigenin counteracted the increase in body and epididymal fat weight.

<p>(A) Body weight gain (%) in mice fed with SD, SD plus treatment with apigenin (10 mg/Kg/day), HFD or HFD plus treatment with apigenin (10 mg/Kg/day) for 8 weeks. Values are means ± SEM, n = 5. ^a<i>P</i><0.05 significant difference vs SD at the respective weeks; *<i>P</i><0.05 significant difference vs HFD at the respective weeks. (B) Epididymal fat weight in mice fed with SD, SD plus treatment with apigenin (10 mg/Kg/day), HFD or HFD plus treatment with apigenin (10 mg/Kg/day) for 8 weeks. Values are means±SEM, n = 5. ^c<i>P</i><0.001, significant difference vs SD; ^$<i>P</i> <0.01 significant difference vs HFD.