The aim was to identify mutations in serum cell-free DNA (cfDNA) associated with disease progression on tamoxifen treatment in metastatic breast cancer (MBC). Sera available at start of therapy, during therapy and at disease progression were selected from 10 estrogen receptor (ER)-positive breast cancer patients. DNA from primary tumor and normal tissue and cfDNA from minute amounts of sera were analyzed by targeted next generation sequencing (NGS) of 45 genes (1,242 exons). At disease progression, stop-gain single nucleotide variants (SNVs) for CREBBP (1 patient) and SMAD4 (1 patient) and non-synonymous SNVs for AKAP9 (1 patient), PIK3CA (2 patients) and TP53 (2 patients) were found. Mutations in CREBBP and SMAD4 have only been occasionall...
Changes in tumor DNA mutation status during chemotherapy can provide insights into tumor biology and...
Background Circulating cell free DNA (cfDNA) is one of the most intriguing and developing topic in...
Identifying disease-related variants is a primary aim of human genetics. In breast cancer, loss of h...
The aim was to identify mutations in serum cell-free DNA (cfDNA) associated with disease progression...
Background: The addition of anti-human epidermal growth factor receptor 2 (HER2)-targeted drugs, suc...
We investigated the utility of the Oncomine Breast cfDNA Assay for detecting circulating tumor DNA (...
Purpose: The purpose of this study was to directly compare mutation profiles in multiple single CTCs...
Background: Breast cancer tissues are heterogeneous and show diverse somatic mutations and somatic c...
PURPOSE: We investigated the utility of the Oncomine Breast cfDNA Assay for detecting circulating tu...
Background Metastatic breast cancer (MBC) remains an incurable disease worldwide. Tumor gene mutatio...
The use of blood-circulating cell-free DNA (cfDNA) as 'liquid-biopsy' is explored worldwide, with ho...
Purpose: In cancer patients, tumor gene mutations contribute to drug resistance and treatment failur...
PURPOSE: The purpose of this study was to directly compare mutation profiles in multiple single CTCs...
The identification of early-stage breast cancer patients at high risk of relapse would allow tailori...
Background:Selection of resistance mutations may play a major role in the development of endocrine r...
Changes in tumor DNA mutation status during chemotherapy can provide insights into tumor biology and...
Background Circulating cell free DNA (cfDNA) is one of the most intriguing and developing topic in...
Identifying disease-related variants is a primary aim of human genetics. In breast cancer, loss of h...
The aim was to identify mutations in serum cell-free DNA (cfDNA) associated with disease progression...
Background: The addition of anti-human epidermal growth factor receptor 2 (HER2)-targeted drugs, suc...
We investigated the utility of the Oncomine Breast cfDNA Assay for detecting circulating tumor DNA (...
Purpose: The purpose of this study was to directly compare mutation profiles in multiple single CTCs...
Background: Breast cancer tissues are heterogeneous and show diverse somatic mutations and somatic c...
PURPOSE: We investigated the utility of the Oncomine Breast cfDNA Assay for detecting circulating tu...
Background Metastatic breast cancer (MBC) remains an incurable disease worldwide. Tumor gene mutatio...
The use of blood-circulating cell-free DNA (cfDNA) as 'liquid-biopsy' is explored worldwide, with ho...
Purpose: In cancer patients, tumor gene mutations contribute to drug resistance and treatment failur...
PURPOSE: The purpose of this study was to directly compare mutation profiles in multiple single CTCs...
The identification of early-stage breast cancer patients at high risk of relapse would allow tailori...
Background:Selection of resistance mutations may play a major role in the development of endocrine r...
Changes in tumor DNA mutation status during chemotherapy can provide insights into tumor biology and...
Background Circulating cell free DNA (cfDNA) is one of the most intriguing and developing topic in...
Identifying disease-related variants is a primary aim of human genetics. In breast cancer, loss of h...