This dissertation focused on developing new econometric methods that have practical implications for the accurate modelling and forecasting of macroeconomic and financial time series. The first chapter investigates changes in the factor structure of the U.S. economy. To do this a two-step Markov-switching static factor estimation procedure is developed and applied to a well-studied U.S. macroeconomic data set. Strong evidence for Markov-switching in the factors processes, with switching variances being most dominant, is found. The results suggest that regime-dependent factor processes are the main explanation for the diverging number of estimated factors in empirical applications and questions the global linearity assumption implicit in lar...