Stress-strain simulation experiments.

<p>We used three values of bond flexibility (<i>s</i>_<i>b</i> values in color) and two values of <i>K</i> (<i>K</i> = 20.0 in panel <b>A</b>, and <i>K</i> = 2.0 in panel <b>B</b>). <b>C</b>: Top view of the colonies at the end of the simulation of colonies perturbed by cell death, for <i>K</i> = 2.0. Color indicates the height, red for higher values and blue for lower values. For this simulation, we used <i>W</i>_<i>D</i> = 1000 and the parameter values specified in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0191089#pone.0191089.s002" target="_blank">S1 Table</a> of the Supporting information.