Simulation results for heterogeneous tissues.

<p>(<b>A</b>) Dependency of parameter κ with the percentage of passive (red dots) and refractory (blue squares) <b>cells</b>. (<b>B</b>) Dependency of parameter τ with the percentage of passive (red dots) and refractory (blue squares) <b>cells</b>. For both graphs, the measured value for the homogeneous <b>tissue</b> is represented by the green open square (<b>A</b>) or dot (<b>B</b>). Values of κ are measured for the whole <b>tissue</b> (active and non-active <b>cells</b>). (<b>C</b>-<b>D</b>) Simulations with passive <b>cells</b>; (<b>E</b>-<b>F</b>) simulations with refractory <b>cells</b>. (<b>C</b>) On a simulation with 95% of passive <b>cells</b> (in red) the remaining 5% of active <b>cells</b> (green) are still able to induce some degree of CE. (<b>D</b>) In a typical simulation with a higher percentage of active <b>cells</b> (here 33%) the active <b>cells</b> align at the center line of the extending <b>tissue</b>. (<b>E</b>) A failed CE for a tissue with less than 20% of active <b>cells</b> (here, 82% of refractory <b>cells</b>, blue). (<b>F</b>) When the percentage of active <b>cells</b> is above 20% (here 54%) the two populations sort out, with the active <b>cells</b> forming an elongated <b>tissue</b> and the refractory <b>cells</b> lying on each side of the structure. Panels (<b>D</b>) and (<b>F</b>) were rotated 90° for visualization purposes.