Spatial distributions of myocytes and fibroblasts in our simulation domain.

<p>Illustrative plots of the distributions of fibroblasts and myocytes, on a representative part of our simulation domain in two dimensions (2D). Fibroblasts (filled black squares) and myocytes (unfilled white squares) are distributed randomly in our simulation domain so that a given grid point contains either a myocyte or a fibroblast, but not both; the percentage of fibroblasts is (A) , (B) , (C) , (D) , and (E) . In (F) we show an illustrative arrangement of myocytes (pink circles) and fibroblasts (blue ellipses); for such an arrangement the diffusion terms are as given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045040#pone.0045040.e156" target="_blank">Eqs. 6</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045040#pone.0045040.e158" target="_blank">8</a>.