Correlation of fold changes in pro-inflammatory cytokines with IPR.

<p>Cytokines released over 18 hours were correlated with intracellular proliferation rates of KN99α-GFP from donor MDMs for 13 donors. Linear regression analysis revealed a significant association with e) MCP-1 (Spearman r = 0.4917; P-value = 0.0467); and no significant associations with a) IFN-γ; b) TNF-α; c) IL-1b; d) IL-6; f) G-CSF; nor g) GM-CSF. Note that only data points that crossed the detection threshold are shown hence not all graphs contain all data points. The fold change in cytokines released by donor MDMs was calculated by dividing the cytokine concentrations (pg/mL) at T18 by those at T0 for each donor.