<p>Sensory information is transmitted with high fidelity across multiple synapses until it reaches the neocortex. There, individual neurons exhibit enormous variability in responses. The source of this diversity in output has been debated. Using transgenic mice expressing the green fluorescent protein coupled to the activity-dependent gene c-fos, we identified neurons with a history of elevated activity in vivo. Focusing on layer 4 to layer 2/3 connections, a site of strong excitatory drive at an initial stage of cortical processing, we find that fluorescently tagged neurons receive significantly greater excitatory and reduced inhibitory input compared with neighboring, unlabeled cells. Differential wiring of layer 2/3 neurons arises early ...
SummaryBackgroundSynaptic interactions between excitatory and inhibitory neocortical neurons are imp...
Almost a hundred years after the recording of the first voltage “spikes”, the question of how neuron...
Summary: Brains vary greatly in neuronal number and density, even across individuals within the same...
†These authors contributed equally to this work. Sensory information is transmitted with high fideli...
Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed ...
SummaryUnbiased methods to assess the firing activity of individual neurons in the neocortex have re...
SummaryNeighboring cortical excitatory neurons show considerable heterogeneity in their responses to...
Identifying the cells and circuits that underlie perception, behavior, and learning is a central goa...
Neighboring cortical excitatory neurons show considerable heterogeneity in their responses to sensor...
Computations in neocortical circuits are predominantly driven by synaptic integration of excitatory ...
Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed ...
How sensory activity contributes to the development of the brain has been a long-standing question ...
The primary motor cortex (M1) consists of layers that are occupied by distinctive excitatory pyramid...
During neocortical development, distinct yet related subtypes of neurons assemble through intracorti...
Neocortical microcircuits are thought to contribute importantly to the sophisticated processing abil...
SummaryBackgroundSynaptic interactions between excitatory and inhibitory neocortical neurons are imp...
Almost a hundred years after the recording of the first voltage “spikes”, the question of how neuron...
Summary: Brains vary greatly in neuronal number and density, even across individuals within the same...
†These authors contributed equally to this work. Sensory information is transmitted with high fideli...
Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed ...
SummaryUnbiased methods to assess the firing activity of individual neurons in the neocortex have re...
SummaryNeighboring cortical excitatory neurons show considerable heterogeneity in their responses to...
Identifying the cells and circuits that underlie perception, behavior, and learning is a central goa...
Neighboring cortical excitatory neurons show considerable heterogeneity in their responses to sensor...
Computations in neocortical circuits are predominantly driven by synaptic integration of excitatory ...
Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed ...
How sensory activity contributes to the development of the brain has been a long-standing question ...
The primary motor cortex (M1) consists of layers that are occupied by distinctive excitatory pyramid...
During neocortical development, distinct yet related subtypes of neurons assemble through intracorti...
Neocortical microcircuits are thought to contribute importantly to the sophisticated processing abil...
SummaryBackgroundSynaptic interactions between excitatory and inhibitory neocortical neurons are imp...
Almost a hundred years after the recording of the first voltage “spikes”, the question of how neuron...
Summary: Brains vary greatly in neuronal number and density, even across individuals within the same...