Neighboring cortical excitatory neurons show considerable heterogeneity in their responses to sensory stimulation. We hypothesized that a subset of layer 2 excitatory neurons in the juvenile (P18 to 27) mouse whisker somatosensory cortex, distinguished by expression of the activity-dependent fosGFP reporter gene, would be preferentially activated by whisker stimulation. In fact, two-photon targeted, dual whole-cell recordings showed that principal whisker stimulation elicits similar amplitude synaptic responses in fosGFP-expressing and fosGFP(-) neurons. FosGFP(+) neurons instead displayed shorter latency and larger amplitude subthreshold responses to surround whisker stimulation. Using optogenetic stimulation, we determined that these neur...
Ascending sensory inputs arriving in layer 1 of the neocortex carry crucial signals for detecting sa...
In this issue of Neuron, Pinto and Dan (2015) performed single-cell calcium imaging in the mouse dor...
The brain processes sensory information in a context- and learning-dependent manner for adaptive beh...
SummaryNeighboring cortical excitatory neurons show considerable heterogeneity in their responses to...
<p>Sensory information is transmitted with high fidelity across multiple synapses until it reaches t...
†These authors contributed equally to this work. Sensory information is transmitted with high fideli...
SummaryUnbiased methods to assess the firing activity of individual neurons in the neocortex have re...
Nearby neurons, sharing the same locations within the mouse whisker map, can have dramatically disti...
A fundamental challenge in neuroscience is to understand the cellular and circuit mechanisms underly...
In the mouse whisker system, sensory information is relayed to the whisker somatosensory cortex by t...
Cortical layer 5B (L5B) thick-tufted pyramidal neurons have reliable responses to whisker stimulatio...
In the mammalian neocortex, segregated processing streams are thought to be important for forming se...
Summary: Initial anatomical and physiological studies suggested that sensory information relayed fro...
Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed ...
Our sensory receptors are faced with an onslaught of different environmental inputs. Each sensory ev...
Ascending sensory inputs arriving in layer 1 of the neocortex carry crucial signals for detecting sa...
In this issue of Neuron, Pinto and Dan (2015) performed single-cell calcium imaging in the mouse dor...
The brain processes sensory information in a context- and learning-dependent manner for adaptive beh...
SummaryNeighboring cortical excitatory neurons show considerable heterogeneity in their responses to...
<p>Sensory information is transmitted with high fidelity across multiple synapses until it reaches t...
†These authors contributed equally to this work. Sensory information is transmitted with high fideli...
SummaryUnbiased methods to assess the firing activity of individual neurons in the neocortex have re...
Nearby neurons, sharing the same locations within the mouse whisker map, can have dramatically disti...
A fundamental challenge in neuroscience is to understand the cellular and circuit mechanisms underly...
In the mouse whisker system, sensory information is relayed to the whisker somatosensory cortex by t...
Cortical layer 5B (L5B) thick-tufted pyramidal neurons have reliable responses to whisker stimulatio...
In the mammalian neocortex, segregated processing streams are thought to be important for forming se...
Summary: Initial anatomical and physiological studies suggested that sensory information relayed fro...
Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed ...
Our sensory receptors are faced with an onslaught of different environmental inputs. Each sensory ev...
Ascending sensory inputs arriving in layer 1 of the neocortex carry crucial signals for detecting sa...
In this issue of Neuron, Pinto and Dan (2015) performed single-cell calcium imaging in the mouse dor...
The brain processes sensory information in a context- and learning-dependent manner for adaptive beh...