Additional file 8: of Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein
- Luise Linsenmeier (5072504)
- Behnam Mohammadi (5072501)
- Sebastian Wetzel (5072507)
- Berta Puig (344828)
- Walker Jackson (5072498)
- Alexander Hartmann (5072495)
- Keiji Uchiyama (140599)
- Suehiro Sakaguchi (140620)
- Kristina Endres (532488)
- Jörg Tatzelt (277508)
- Paul Saftig (77057)
- Markus Glatzel (36155)
- Hermann Altmeppen (423101)
Publication date
April 2018
DOIAbstract
(.jpg) Embryonic fibroblasts (MEF) of ADAM10 knockout mice accumulate PrPC. Representative western blot of media supernatants and lysates of wild-type (WT) and ADAM10 KO MEF. Lack of shedding and no increased compensatory release of PrP is observed in ADAM10 KO cells. ADAM10 is shown in lysates as a proof of genotypes. Increased levels of PrPC are found in lysates and quantified by referring to β-actin (n = 8; p = 0.00005). (JPEG 131 kb
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