Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
- Solimena, Michele
- Schulte, Anke M.
- Marselli, Lorella
- Ehehalt, Florian
- Richter, Daniela
- Kleeberg, Manuela
- Mziaut, Hassan
- Knoch, Klaus-Peter
- Parnis, Julia
- Bugliani, Marco
- Siddiq, Afshan
- Jörns, Anne
- Burdet, Frédéric
- Liechti, Robin
- Suleiman, Mara
- Margerie, Daniel
- Syed, Farooq
- Distler, Marius
- Grützmann, Robert
- Petretto, Enrico
- Moreno-Moral, Aida
- Wegbrod, Carolin
- Sönmez, Anke
- Pfriem, Katja
- Friedrich, Anne
- Meinel, Jörn
- Wollheim, Claes B.
- Baretton, Gustavo B.
- Scharfmann, Raphael
- Nogoceke, Everson
- Bonifacio, Ezio
- Sturm, Dorothée
- Meyer-Puttlitz, Birgit
- Boggi, Ugo
- Saeger, Hans-Detlev
- Filipponi, Franco
- Lesche, Mathias
- Meda, Paolo
- Dahl, Andreas
- Wigger, Leonore
- Xenarios, Ioannis
- Falchi, Mario
- Thorens, Bernard
- Weitz, Jürgen
- Bokvist, Krister
- Lenzen, Sigurd
- Rutter, Guy A.
- Froguel, Philippe
- von Bülow, Manon
- Ibberson, Mark
- Marchetti, Piero
DOIAbstract
Aims/hypothesis: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in Diabetes (IMIDIA) consortium (www.imidia.org) established a comprehensive, unique multicentre biobank of human islets and pancreas tissues from organ donors and metabolically phenotyped pancreatectomised patients (PPP). Methods: Affymetrix microarrays were used to assess the islet transcriptome of islets isolated either by enzymatic digestion from 103 organ donors (OD), including 84 non-diabetic and 19 type 2 diabetic individuals, or by laser capt...
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